Marc Diamond, M.D. Director, Center for Alzheimer's and Neurodegenerative Diseases Professor & Director Endowed Title Effie Marie Cain Distinguished University Chair in Alzheimer's Research School Medical School Department Center for Alzheimer's and Neurodegenerative Diseases | Neurology | Neuroscience Graduate Programs Molecular Biophysics, Neuroscience You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae Marc Diamond, M.D., is the founding director of the Center for Alzheimer's and Neurodegenerative Diseases (CAND). The CAND is a multidisciplinary translational research program comprised of 11 faculty members who are focused on fundamental disease mechanisms. Its mission is to develop more effective diagnosis and therapy for Alzheimer's and related disorders. Marc's original discoveries linked common conditions such as Alzheimer's to rare infectious prion disorders such as Creutzfeldt-Jakob and "mad cow" disease. His lab determined that abnormal assemblies of the tau protein move between cells and serve as templates for their own replication, and has elucidated the mechanisms of this process. This has transformed our understanding of how different neurodegenerative diseases arise and why they progress. His ideas underlie new treatment strategies currently being pursued by the pharmaceutical industry, and his methods are employed worldwide for neurodegenerative diseases research. Marc studied history at Princeton, and received his M.D. (1993) at UCSF, where he then completed residency training in Neurology in 1997, serving as chief resident in his final year. At UCSF he worked with Keith Yamamoto, Ph.D. as a Howard Hughes Medical Student Research Fellow (1989-1991) and as a postdoctoral fellow (1997-2001). He was a faculty member in the Department of Neurology at UCSF from 2002-2009, before moving to Washington University in St. Louis in 2009 as the David Clayson Professor of Neurology. Since 2014, he has been a professor of Neurology and Neuroscience at UT Southwestern Medical Center. Marc is an internationally recognized expert in neurodegenerative disease, and lectures frequently at major universities and scientific meetings around the world. His research has been cited thousands of times by his scientific colleagues. Education Graduate School Princeton University (1987), History Medical School University of California-San F (1993), Medicine Research Interest Cell and Molecular Biology Neurodegenerative Diseases Neuroscience Prion Biology Publications Featured Publications Seed-competent tau monomer initiates pathology in a tauopathy mouse model. Mirbaha H, Chen D, Mullapudi V, Terpack SJ, White CL, Joachimiak LA, Diamond MI, J Biol Chem 2022 Jun 102163 RNA induces unique tau strains and stabilizes Alzheimer's disease seeds. Zwierzchowski-Zarate AN, Mendoza-Oliva A, Kashmer OM, Collazo-Lopez JE, White CL, Diamond MI, J Biol Chem 2022 Jun 102132 The dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification. Kolay S, Vega AR, Dodd DA, Perez VA, Kashmer OM, White CL, Diamond MI, J Biol Chem 2022 May 102014 VCP suppresses proteopathic seeding in neurons. Zhu J, Pittman S, Dhavale D, French R, Patterson JN, Kaleelurrrahuman MS, Sun Y, Vaquer-Alicea J, Maggiore G, Clemen CS, Buscher WJ, Bieschke J, Kotzbauer P, Ayala Y, Diamond MI, Davis AA, Weihl C, Mol Neurodegener 2022 Apr 17 1 30 Deep learning reveals disease-specific signatures of white matter pathology in tauopathies. Vega AR, Chkheidze R, Jarmale V, Shang P, Foong C, Diamond MI, White CL, Rajaram S, Acta Neuropathol Commun 2021 Oct 9 1 170 Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns. Stopschinski BE, Del Tredici K, Estill-Terpack SJ, Ghebremdehin E, Yu FF, Braak H, Diamond MI, Acta Neuropathol Commun 2021 Oct 9 1 164 Tau seeding in chronic traumatic encephalopathy parallels disease severity. Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI, Acta Neuropathol 2021 Oct Tau strains shape disease. Vaquer-Alicea J, Diamond MI, Joachimiak LA, Acta Neuropathol 2021 Jul 142 1 57-71 Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF. Hitt BD, Vaquer-Alicea J, Manon VA, Beaver JD, Kashmer OM, Garcia JN, Diamond MI, Acta Neuropathol Commun 2021 05 9 1 99 Alzheimer's disease risk modifier genes do not affect tau aggregate uptake, seeding or maintenance in cell models. Kolay S, Diamond MI, FEBS Open Bio 2020 09 10 9 1912-1920 Results 1-10 of 46 1 2 3 4 5 Next Last Honors & Awards Distinguished ChairBrain Injury and Repair (2014) Scholar-Innovator AwardHarrington (2012) Foundation AwardRuth K. Broad (2010) Endowed ChairDavid Clayson Professor of Neurology (2009) Leadership AwardHuntington's Disease Society of America (2007) Sandler Opportunity Award (2007)
